Effect of protease-treated royal jelly on plasma and liver lipids in rats fed on a high fat plus high cholesterol diet [Japanese]

摘要

The effect of protease-treated royal jelly (PRJ) on plasma and liver lipids in rats fed a high fat plus high cholesterol (F) diet was investigated in comparison with untreated royal jelly (RJ). The amount of total cholesterol in plasma, which was increased by the F diet, was decreased by royal jelly medication. That lowering effect of cholesterol level in PRJ group was more markedly than that in untreated RJ group. The ratio of plasma HDL-cholesterol to total plasma cholesterol in PRJ group was increased more effective than that in untreated RJ group. Although the amount of total cholesterol in the liver was declined by royal jelly medication, there was no significant difference of its tendency between PRJ and untreated RJ groups. The amounts of fecal excretion of cholesterol and bile acid increased in the F group, those excreting amounts were enhanced by the addition of royal jelly, especially, those in PRJ group were significantly higher than those in F group. These results suggest that the lowering effect of cholesterol in rat plasma by PRJ is due to an increase of the fecal excretion of cholesterol and bile acid, and that PRJ is more valuable than RJ.