The safety of adjuvants in influenza vaccines during pregnancy: What do we know and why do we need them?

摘要

The high mortality rates observed among pregnant women during the 1957 through 1958 influenza pandemic prompted the US Surgeon General to issue a report in 1960 that recommended routine seasonal influenza vaccination for pregnant women.1 During the past half century, recommendations in the United States have evolved, with influenza vaccination recommended for all pregnant women regardless of trimester beginning in 2004. Despite these recommendations, influenza vaccination rates among pregnant women were generally low (< 15%) until the 2009 H1N1 influenza A pandemic when vaccination rates increased to about 50%.