Family history and personal genomics as tools for improving health in an era of evidence-based medicine.

摘要

A 2009 state of science NIH conference on "Family History and Improving Health" concluded that there was insufficient evidence to support the routine use of family history as a screening tool for risk of common complex conditions in primary care. This conclusion, though disappointing, was not unexpected in view of the fact that family history (FH) has been a core element of clinical care long before the evidence-based medicine paradigm was even proposed. Very few studies have evaluated whether or not FH tools used for risk assessment have clinical utility in primary care settings.