Pyruvate in reduced osmolarity oral rehydration salt corrected lactic acidosis in sever scald rats

摘要

BackgroundA novel pyruvate-based oral rehydration salt (Pyr-ORS) was demonstrated of superiority over bicarbonate- or citrate-based one to preserve organ function and correct lactic acidosis in rehydration of lethal shock in animals. This study further compared these effects between low-osmolar Pyr-ORS and equimolar citrate-based counterpart. MethodsEighty rats, using a fatal burn shock model, were randomized into four groups (two subgroups per group:n?=?10): the sham group (group SR), Pyr-ORS group (group PR), WHO-ORS III group (group CR), and no rehydration group. ORS was delivered by manual gavage during 24?h following burns. Oral administration consisted of half of counted volume in the initial 8?h plus the rest in the later 16?h. Systemic hemodynamics, visceral organ surface blood flow, organ function, and metabolic acidosis were determined at 8?h and 24?h after burn. Another set of rats with identical surgical procedures without tests was observed for survival. ResultsSurvival was markedly improved in the groups PR and CR; the former showed a higher survival rate than the latter at 24?h (40%versus20%,P?