Linc‐PINT acted as a tumor suppressor by sponging miR‐543 and miR‐576‐5p in esophageal cancer

摘要

Abstract This manuscript aimed to investigate linc‐PINT's role as a tumor suppressor and its downstream microRNAs (miRNAs) in esophageal cancer. Log‐rank, Cox, and nomogram were used for survival analysis. Quantitative real‐time polymerase chain reaction was used to evaluate the expression. Cell counting kit‐8 was used for proliferation tests. As for in vivo experiments, low expression of linc‐PINT was associated with better prognosis; besides, the nomogram indicated that linc‐PINT, miR‐543, and miR‐576‐5p served well in predicting the survival rate. As for the in vitro experiments, linc‐PINT could directly regulate miR‐543 and miR‐576‐5p to inhibit the proliferation of Eca‐109 cell line. In conclusion, linc‐PINT–miR‐543/miR‐576‐5p pathway could predict the prognosis and provide novel therapeutic targets for esophageal cancer.