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SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV‐2

机译：SIV祖先演变对艾滋病毒：SIVSM适应对HIV-2的人源化鼠标替代模型

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Abstract > How SIV progenitors evolved into deadly HIV‐1 and HIV‐2 following initial cross‐species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV‐2. Increased viral virulence to human CD4 + T cells and adaptive genetic changes were observed during serial passages. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：ID =“JMP12380-ABS-AB-0001”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >如何SIV祖先演变为致命的HIV- 初始跨物种传输后1和HIV-2仍然是一个谜。在这里，我们使用人源化的小鼠作为人类替代品系，以评估SIVSM进化到HIV-2。在串行通道期间观察到对人CD4 + </ sup> T细胞和适应性遗传变化增加的病毒毒力增加。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-36449/'>《Journal of medical primatology》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共4页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schmitt Kimberly&option=202" target="_blank" rel="nofollow">Schmitt Kimberly;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Curlin James&option=202" target="_blank" rel="nofollow">Curlin James;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kumar Dipu Mohan&option=202" target="_blank" rel="nofollow">Kumar Dipu Mohan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Remling‐Mulder Leila&option=202" target="_blank" rel="nofollow">Remling‐Mulder Leila;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Feely Stephanie&option=202" target="_blank" rel="nofollow">Feely Stephanie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stenglein Mark&option=202" target="_blank" rel="nofollow">Stenglein Mark;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OConnor Shelby&option=202" target="_blank" rel="nofollow">OConnor Shelby;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Marx Preston&option=202" target="_blank" rel="nofollow">Marx Preston;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Akkina Ramesh&option=202" target="_blank" rel="nofollow">Akkina Ramesh;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Microbiology Immunology and PathologyColorado State UniversityFort Collins Colorado;</p> <p>Department of Microbiology Immunology and PathologyColorado State UniversityFort Collins Colorado;</p> <p>Department of Microbiology Immunology and PathologyColorado State UniversityFort Collins Colorado;</p> <p>Department of Microbiology Immunology and PathologyColorado State UniversityFort Collins Colorado;</p> <p>Tulane National Primate Research CenterCovington Louisiana;</p> <p>Department of Microbiology Immunology and PathologyColorado State UniversityFort Collins Colorado;</p> <p>University of Wisconsin School of Medicine and Public HealthMadison Wisconsin;</p> <p>Tulane National Primate Research CenterCovington Louisiana;</p> <p>Department of Microbiology Immunology and PathologyColorado State UniversityFort Collins Colorado;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/40383.html" title="灵长目">灵长目;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cross‐species transmission of SIV&option=203" rel="nofollow">cross‐species transmission of SIV;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=modeling SIV evolution using humanized mice&option=203" rel="nofollow">modeling SIV evolution using humanized mice;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SIV evolution into HIV using humanized mice&option=203" rel="nofollow">SIV evolution into HIV using humanized mice;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SIVsm evolution into HIV‐2&option=203" rel="nofollow">SIVsm evolution into HIV‐2;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=viral evolution of SIVsm into HIV‐2&option=203" rel="nofollow">viral evolution of SIVsm into HIV‐2;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SIV pathogenesis in humanized mice&option=203" rel="nofollow">SIV pathogenesis in humanized mice;</a> </p> <div class="translation"> 机译：SIV的跨物种传播;使用人源化小鼠建模SIV演化;使用人源化小鼠的SIV进化;SIVSM进化进入HIV-2;SIVSM的病毒演变为HIV-2;SIV在人源化小鼠中的发病机制; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025993024.html">SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward 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