Study on the Neuroprotective Effect and Mechanism of RasGRP1 After Oxygen Deprivation and Reperfusion Based on Mutual Information and Artificial Neural Network

摘要

An artificial neural network (ANN) algorithm was developed and applied to predict ischemic tissue fate on three stroke groups: 30-, 60-minute, and permanent middle cerebral artery occlusion in rats. Cerebral blood flow (CBF), apparent diffusion coefficient (ADC), and spin-spin relaxation time constant (T2) were acquired during the acute phase up to 3 hours and again at 24 hours followed by histology. Our research mainly focused on the neuroprotective effect and mechanism of RasGRP1 after oxygen deprivation and reperfusion based on mutual information and ANN technique, and it is demonstrated that activation of phosphorylated nuclear transcription factor is caused by vasoconstriction aggravating ischemia and deficiency.