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首页> 外文期刊>Journal of toxicology and environmental health, Part A >Antivibration Gloves: Effects on Vascular and Sensorineural Function, an Animal Model
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Antivibration Gloves: Effects on Vascular and Sensorineural Function, an Animal Model

机译:防真手套:对血管和传感器功能的影响,动物模型

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摘要

Anti-vibration gloves have been used to block the transmission of vibration from powered hand tools to the user, and to protect users from the negative health consequences associated with exposure to vibration. However, there are conflicting reports as to the efficacy of gloves in protecting workers. The goal of this study was to use a characterized animal model of vibration-induced peripheral vascular and nerve injury to determine whether antivibration materials reduced or inhibited the effects of vibration on these physiological symptoms. Rats were exposed to 4 h of tail vibration at 125 Hz with an acceleration 49 m/s(2). The platform was either bare or covered with antivibrating glove material. Rats were tested for tactile sensitivity to applied pressure before and after vibration exposure. One day following the exposure, ventral tail arteries were assessed for sensitivity to vasodilating and vasoconstricting factors and nerves were examined histologically for early indicators of edema and inflammation. Ventral tail artery responses to an alpha 2C-adrenoreceptor agonist were enhanced in arteries from vibration-exposed rats compared to controls, regardless of whether antivibration materials were used or not. Rats exposed to vibration were also less sensitive to pressure after exposure. These findings are consistent with experimental findings in humans suggesting that antivibration gloves may not provide protection against the adverse health consequences of vibration exposure in all conditions. Additional studies need to be done examining newer antivibration materials.
机译:已经使用防振手套来阻止从动力手动工具到用户的振动传递,并保护用户免受与暴露于振动相关的负面健康后果。但是,关于手套在保护工人的疗效存在矛盾的报告。本研究的目标是使用振动诱导的外周血血管和神经损伤的表征动物模型,以确定抗振材料是否减少或抑制振动对这些生理症状的影响。大鼠在125Hz下暴露于4小时,加速49m / s(2)。平台裸露或覆盖抗振手套材料。测试大鼠以在振动暴露之前和之后施加压力的触觉敏感性。曝光后的一天,评估腹侧尾动术尿尾动脉对血管舒张的敏感性,并且在医院的早期指标和炎症的早期指标中检查血管电压和神经。与对照相比,在振动暴露大鼠的动脉中增强了对α2C-肾上腺菌属激动剂的腹侧尾动响应,无论是否使用抗抗衡材料,都会增强。暴露于振动暴露于振动的大鼠对暴露后的压力也不敏感。这些发现与人类的实验结果一致,提示防振手套可能无法在所有条件下对振动暴露的不利健康后果提供保护。需要进行额外的研究检查较新的防振材料。

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  • 作者单位

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

    NIOSH Engn &

    Controls Technol Branch Morgantown WV 26505 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学(毒理学);
  • 关键词

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