Synthesis of novel spirofused spiropyrrolidine 1,3-indanedione derivatives via 1,3-dipolar cycloaddition reactions

摘要

The successful synthesis of novel spirofused spiropyrrolidine 1,3-indanedione derivatives using 1,3-dipolar cycloaddition reactions is reported. 1-Benzyl-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones prepared via Knoevenagel condensation of 1-benzyl-4-piperidinone with aromatic aldehydes underwent a one-pot, three-component reaction with benzylamines and ninhydrin in ethanol to afford the desired products.