Facile, efficient, catalyst-free, ultrasound-assisted one-pot green synthesis of triazole derivatives

摘要

A novel and efficient ultrasonic-assisted one-pot tandem reaction has been developed for synthesis of triazole derivatives with excellent yield (94-98%) in short reaction time (< 6 min) in the absence of catalyst under ethanol solvent condition. All synthesized molecules were well identified and characterized using various spectral techniques including(1)H,C-13, and(15)N nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) analyses. This green protocol offers many benefits including environmental friendliness, clean and simple operation, cost-effectiveness, short reaction time, easy work-up, excellent yield, and reduced waste production, making the method "green" and "ecofriendly benign." Graphic abstract