Contribution of backward and forward wave pressures to age-related increases in aortic pressure in a community sample not receiving antihypertensive therapy

摘要

Abstract Reports on the contribution of aortic forward (Pf) and backward (Pb) wave pressures to age-related increases in central aortic pulse pressure (PPc) have been confounded by the use of participants receiving antihypertensive therapy. We assessed the relative contribution of Pf and Pb to age-related increases in PPc (radial applanation tonometry and SphygmoCor software using an assumed triangular wave for wave separation analysis) in 892 community participants not receiving antihypertensive therapy. We validated our results using aortic flow waves (echocardiography) for wave separation analysis in 254 of these participants. In multivariate regression models in those aged 50?years, adjustments for Pf (β-coefficient: 0.25?±?0.06 vs. 0.74?±?0.08; P ? P ? P ? P ? P ? P ? Highlights ? In untreated community participants aged ? In contrast, in untreated participants aged ≥50?years of age, Pb and Pf contributed to age-related increases in PPc. ? In the participants aged ≥50?years, the Pb effects were markedly diminished by adjustments for Pf. ? Pb contributes to age-related increases in aortic PPc, but ≥50?years, this effect is attributed to the impact of Pf on Pb. ]]>