Pharmacokinetic and ocular microdialysis study of oral ginkgo biloba extract in rabbits by UPLC-MS/MS determination

Wang Shuya; Li Ding; Pi Jiaxin; Li Wen; Zhang Bing; Qi Dongli; Li Nan; Guo Pan; Liu Zhidong

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Pharmacokinetic and ocular microdialysis study of oral ginkgo biloba extract in rabbits by UPLC-MS/MS determination

机译：UPLC-MS / MS测定兔口服银杏叶提取物的药代动力学和眼镜菌研究

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Objectives The purpose of this work was to determine and investigate the absorption of ginkgo terpenoids (GT) in plasma and aqueous humour after oral administration of ginkgo biloba extract (GBE) by UPLC-MS/MS method.

机译：目的这项工作的目的是通过UPLC-MS / MS法在口服施用银杏提取物（GBE）后测定和研究血浆和含水幽默中的银杏萜素（GT）的吸收。

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来源
《Journal of Pharmacy and Pharmacology》 |2017年第11期|共12页
作者
Wang Shuya; Li Ding; Pi Jiaxin; Li Wen; Zhang Bing; Qi Dongli; Li Nan; Guo Pan; Liu Zhidong;
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作者单位

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

Sine Promod Pharmaceut Co Shanghai Peoples R China;

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

Tianjin Univ Tradit Chinese Med Tianjin State Key Lab Modern Chinese Med Tianjin Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
ginkgo biloba extract; ginkgo terpenoids; microdialysis; pharmacokinetic;

机译：银杏叶提取物;银杏萜类化合物;微透析;药代动力学;

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专利

1. Pharmacokinetic and ocular microdialysis study of oral ginkgo biloba extract in rabbits by UPLC-MS/MS determination [J] . Wang Shuya, Li Ding, Pi Jiaxin, Journal of Pharmacy and Pharmacology . 2017,第11期

机译：UPLC-MS / MS测定兔口服银杏叶提取物的药代动力学和眼镜菌研究
2. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats [J] . Chen Zhi-peng, Sun Jun, Chen Hong-xuan, Fitoterapia . 2010,第8期

机译：口服银杏叶提取物，银杏叶提取物磷脂复合物和银杏叶提取物固体分散体后，槲皮素，山奈酚和异鼠李素的比较药代动力学和生物利用度研究
3. Determination of Ginkgolides A, B, C, J and Bilobalide in Plasma by LC-ESI (-)/MS/MS (QQQ) and its Application to the Pharmacokinetic Study of Ginkgo Biloba Extract in Rats [J] . Z. Yan-Yan, C. Li-Li, S. Cuo-Ming, Drug research . 2016,第10期

机译：LC-ESI（-）/ MS / MS（QQQ）测定血浆中的银杏内酯A，B，C，J和双叶内酯及其在大鼠银杏叶提取物药代动力学研究中的应用
4. Development of self-microemulsifying drug delivery systems (SMEDDS)for improving oral bioavailability of Ginkgo biloba extract in dogs [C] . Zhong-gui He, Jing-ling Tang, Jin Sun, Annual meeting exposition of the Controlled Release Society . 2005

机译：开发用于改善狗银杏叶提取物口服生物利用度的自微乳化药物递送系统（SMEDDS）
5. Neuroprotective Mechanisms of Ginkgo Biloba extract (EGb761) in Alzheimer's Disease. [D] . Shi, Chun. 2010

机译：银杏叶提取物（EGb761）在阿尔茨海默氏病中的神经保护机制。
6. Simultaneous determination by UPLC-MS/MS of seven bioactive compounds in rat plasma after oral administration of Ginkgo biloba tablets: application to a pharmacokinetic study [O] . Wen-ping Wang, Na Liu, Qian Kang, 2014

机译：口服银杏片剂后通过UPLC-MS / MS同时测定大鼠血浆中的七种生物活性化合物：在药代动力学研究中的应用
7. Pharmacokinetic Study of Thirteen Ingredients after the Oral Administration of Flos Chrysanthemi Extract in Rats by UPLC-MS/MS [O] . Qi Jia, Xuhua Huang, Guangzhe Yao, 2020

机译：UPLU-MS / MS大鼠口服氟菊提取物口服施用13种成分的药代动力学研究

Pharmacokinetic and ocular microdialysis study of oral ginkgo biloba extract in rabbits by UPLC-MS/MS determination

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