Sparfloxacin Metal Complexes with Nucleosides: Potentiometric and Spectral Studies

摘要

Potentiometric measurements of the interaction of sparfloxacin (SPFX) and metal ions Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with nucleosides (NS) adenosine, guanosine, cytidine and inosine were carried out. The complexes formed are monoprotonated M(II)(SPFX)(HNS) species, where the nucleoside acts as a secondary ligand in its protonated form. The formation of ternary complexes of some systems was confirmed by UV-Visible measurements in solution. The binding constant of M(II)-SPFX complexes were measured in Tris-HCl buffer solution (pH = 7.4).