Identification and metabolite profiling of alkaloids in aerial parts of        <i >Papaver rhoeasPapaver rhoeas        by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry

Oh Jae‐Hyeon; Ha In Jin; Lee Min Young; Kim Eun‐Ok; Park Dain; Lee Jun‐Hee; Lee Seok‐Geun; Kim Do‐Wan; Lee Tae‐Ho; Lee Eui‐Ju; Kim Chang‐Kug

摘要

Abstract > Papaver plants can produce diverse bioactive alkaloids. Papaver rhoeas Linnaeus (common poppy or corn poppy) is an annual flowering medicinal plant used for treating cough, sleep disorder, and as a sedative, pain reliever, and food. It contains various powerful alkaloids like rhoeadine, benzylisoquinoline, and proaporphine. To investigate and identify alkaloids in the aerial parts of P. rhoeas , samples were collected at different growth stages and analyzed using liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry. A liquid chromatography with mass spectrometry method was developed for the identification and metabolite profiling of alkaloids for P. rhoeas by comparing with Papaver somniferum . Eighteen alkaloids involved in benzylisoquinoline alkaloid biosynthesis were used to optimize the liquid chromatography gradient and mass spectrometry conditions. Fifty‐five alkaloids, including protoberberine, benzylisoquinoline, aporphine, benzophenanthridine, and rhoeadine‐type alkaloids, were identified authentically or tentatively by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry in samples taken during various growth stages. Rhoeadine alkaloids were observed only in P. rhoeas samples, and codeine and morphine were tentatively identified in P. somniferum . The liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry method can be a powerful tool for the identification of diverse metabolites in the genus Papaver . These results may help understand the biosynthesis of alkaloids in P. rhoeas and evaluate the quality of this plant for possible medicinal app </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 罂粟类植物可以产生各种生物活性生物碱。 Papaver rhoeas </ i> Linnaeus（普通罂粟或玉米罂粟）是一种用于治疗咳嗽，睡眠障碍和镇静，止痛药和食物的年度开花药用植物。它含有各种强大的生物碱，如Rhoeadine，苄基异喹啉和海莨菪碱等。研究和鉴定 p的空中部位中的生物碱。在不同的生长阶段收集样品并使用液相色谱法分析样品，并使用与四极杆飞行时间串联质谱法相结合。开发了具有质谱法的液相色谱，用于鉴定和代谢物分析，用于 p。 Rhoeas </ i>通过与 Papaver Somniferum </ i>进行比较。参与苄基异喹啉生物碱生物合成的18个生物碱用于优化液相色谱梯度和质谱条件。在各种生长阶段中采用的样品中，通过液相色谱法在各种生长阶段采用的样品中偶联或暂时地鉴定55个生物碱，包括促富溴苯，苄基异喹啉，嗜啡，苯并异喹啉和雌酮类生物碱。仅在 p中观察到rhoeadine生物碱。 Rhoeas </ i>样品和可待因和吗啡在 p中暂时鉴定。 Somniferum </ i>。液相色谱与四极杆飞行时间串联质谱法相结合，可以是鉴定在罂粟类属中不同代谢物的强大工具。这些结果可能有助于了解在 p中的生物碱的生物合成。 Rhoeas </ i>并评估该植物的质量，用于可能的药用应用程序 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science. 》</a> <b style="margin: 0 2px;">|</b><span>2018年第12期</span><b style="margin: 0 2px;">|</b> <span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oh Jae‐Hyeon&option=202" target="_blank" rel="nofollow">Oh Jae‐Hyeon;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ha In Jin&option=202" target="_blank" rel="nofollow">Ha In Jin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Min Young&option=202" target="_blank" rel="nofollow">Lee Min Young;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kim Eun‐Ok&option=202" target="_blank" rel="nofollow">Kim Eun‐Ok;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Park Dain&option=202" target="_blank" rel="nofollow">Park Dain;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Jun‐Hee&option=202" target="_blank" rel="nofollow">Lee Jun‐Hee;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Seok‐Geun&option=202" target="_blank" rel="nofollow">Lee Seok‐Geun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kim Do‐Wan&option=202" target="_blank" rel="nofollow">Kim Do‐Wan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Tae‐Ho&option=202" target="_blank" rel="nofollow">Lee Tae‐Ho;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Eui‐Ju&option=202" target="_blank" rel="nofollow">Lee Eui‐Ju;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kim Chang‐Kug&option=202" target="_blank" rel="nofollow">Kim Chang‐Kug;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Genomics DivisionRural Development Administration (RDA)Jeollabuk‐do Republic of Korea;</p> <p>Korean Medicine Clinical Trial Center (K‐CTC)Kyung Hee University Korean Medicine HospitalSeoul Republic of Korea;</p> <p>Korean Medicine Clinical Trial Center (K‐CTC)Kyung Hee University Korean Medicine HospitalSeoul Republic of Korea;</p> <p>Korean Medicine Clinical Trial Center (K‐CTC)Kyung Hee University Korean Medicine HospitalSeoul Republic of Korea;</p> <p>Korean Medicine Clinical Trial Center (K‐CTC)Kyung Hee University Korean Medicine HospitalSeoul Republic of Korea;</p> <p>Korean Medicine Clinical Trial Center (K‐CTC)Kyung Hee University Korean Medicine HospitalSeoul Republic of Korea;</p> <p>Korean Medicine Clinical Trial Center (K‐CTC)Kyung Hee University Korean Medicine HospitalSeoul Republic of Korea;</p> <p>Genomics DivisionRural Development Administration (RDA)Jeollabuk‐do Republic of Korea;</p> <p>Genomics DivisionRural Development Administration (RDA)Jeollabuk‐do Republic of Korea;</p> <p>Korean Medicine Clinical Trial Center (K‐CTC)Kyung Hee University Korean Medicine HospitalSeoul Republic of Korea;</p> <p>Genomics DivisionRural Development Administration (RDA)Jeollabuk‐do Republic of Korea;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=alkaloids&option=203" rel="nofollow">alkaloids;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=liquid chromatography&option=203" rel="nofollow">liquid chromatography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=metabolite profiling&option=203" rel="nofollow">metabolite profiling;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Papaver rhoeas&option=203" rel="nofollow">Papaver rhoeas;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Papaver somniferum&option=203" rel="nofollow">Papaver somniferum;</a> </p> <div class="translation"> 机译：生物碱;液相色谱;代谢物分析;罂粟属rhoeas;罂粟属somniferum; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025846926.html">Identification and metabolite profiling of alkaloids in aerial parts of <i >Papaver rhoeasPapaver rhoeas by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oh Jae‐Hyeon&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Oh Jae‐Hyeon,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ha In Jin&option=202" target="_blank" rel="nofollow" class="tuijian_auth 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break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：固相萃取-超高效液相色谱-质谱联用（SPE-UPLC-MS）进行DXP代谢产物鉴定和DXP通路的系统诊断 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130433961255.html">Tandem and time of flight mass spectrometry method involves determining time of flight and position of arrival of fragments, and identifying fragment pairs in measured positions and times of flight to generate dissociation spectra</a> <b>[P]</b> . <span> 外国专利：  FR2895834A1 </span> <span> . 2007-07-06</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：串联和飞行时间质谱法涉及确定飞行时间和碎片到达的位置，并在测量的位置和飞行时间中识别碎片对以生成解离光谱 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div 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Identification and metabolite profiling of alkaloids in aerial parts of Papaver rhoeasPapaver rhoeas by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry

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