Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold‐stagnation and blood‐stasis primary dysmenorrhoea after the administration of        <i >Leonurus japonicusLeonurus japonicus        houtt electuary

Wen Yan‐qing; Gong Li‐ying; Wang Lin; Zhao Nan; Sun Qi; Kamara Mohamed Olounfeh; Ma Hai‐ying; Meng Fan‐hao

摘要

Abstract > Leonurus japonicus houtt, a well‐known herb of traditional Chinese medicine, is widely used to treat gynaecological diseases. In this study, a rapid and sensitive liquid chromatography with tandem mass spectrometry method for simultaneously quantifying leonurine and stachydrine, the two main bioactive components in Leonurus japonicus houtt, was developed and validated. Plasma samples were prepared by protein precipitation with acetonitrile and separation by a Hewlett Packard XDB‐C8 column (150?×?4.6?mm, id, 5?μm) equipped with a gradient elution system containing methanol‐water and 0.1% formic acid at a flow‐rate of 0.4?mL/min. Components were then detected by a mass spectrometer in positive electrospray ionization mode. This method showed good linearity, precision, accuracy, recovery, stability, and negligible matrix effects, which were within acceptable ranges. The method was successfully applied to compare the pharmacokinetics in normal rats and rats with cold‐stagnation and blood‐stasis primary dysmenorrhoea treated with Leonurus?japonicus ?houtt electuary. The result showed significant differences ( p ??0.05) in the pharmacokinetic parameters between the primary dysmenorrhoea and normal groups. This result implied that Leonurus japonicus houtt electuary remained longer and was absorbed slower in rats with primary dysmenorrhoea and exhibited higher bioavailability and peak concentration. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> > Leonurus japonicus </ i> Houtt，繁体中文知名的草药药物，广泛用于治疗妇科疾病。在该研究中，开发并验证了一种用于同时定量白嘌呤和STOHYRINE的串联质谱法的快速和敏感的液相色谱，用于同时定量白嘌呤和STOHYRINE，并验证了 Leonurus japonicus </ i> Houtt中的两个主要的生物活性成分。通过用乙腈沉淀制备血浆样品，并通过Hewlett Packard XDB-C8柱分离（150××4.6×4.6μm，ID，5?μm），配备含有甲醇 - 水和0.1％甲酸的梯度洗脱系统流速为0.4？ml / min。然后通过阳性电喷雾电离模式中的质谱仪检测组分。该方法显示出良好的线性，精度，精度，恢复，稳定性和可忽略的矩阵效应，这是可接受的范围内。该方法已成功应用以将常规大鼠和大鼠的药代动力学与冷滞后和血液 - 瘀血粥样蛋白酶进行比较，用 Leonurus治疗，japonicus </ i>？Houtt Electeary。结果表明，在初级吞咽物瘤和正常组之间的药代动力学参数中的显着差异（ pβ.<0.05）。这一结果暗示了 Leonurus japonicus </ i> Houtt Electeon仍然较长，并且在原发性痛经大鼠中被吸收较慢，并且表现出更高的生物利用度和峰值浓度。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2019年第9期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wen Yan‐qing&option=202" target="_blank" rel="nofollow">Wen Yan‐qing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gong Li‐ying&option=202" target="_blank" rel="nofollow">Gong Li‐ying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Lin&option=202" target="_blank" rel="nofollow">Wang Lin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhao Nan&option=202" target="_blank" rel="nofollow">Zhao Nan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sun Qi&option=202" target="_blank" rel="nofollow">Sun Qi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kamara Mohamed Olounfeh&option=202" target="_blank" rel="nofollow">Kamara Mohamed Olounfeh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ma Hai‐ying&option=202" target="_blank" rel="nofollow">Ma Hai‐ying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Meng Fan‐hao&option=202" target="_blank" rel="nofollow">Meng Fan‐hao;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>School of pharmacyChina Medical UniversityShenyang P. R. China;</p> <p>Department of Laboratory MedicineThe People's Hospital of Liaoning ProvinceShenyang P. R. China;</p> <p>School of pharmacyChina Medical UniversityShenyang P. R. China;</p> <p>School of pharmacyChina Medical UniversityShenyang P. R. China;</p> <p>School of pharmacyChina Medical UniversityShenyang P. R. China;</p> <p>School of pharmacyChina Medical UniversityShenyang P. R. China;</p> <p>The Fourth Affiliated Hospital of China Medical UniversityShenyang P. R. China;</p> <p>School of pharmacyChina Medical UniversityShenyang P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=leonurine&option=203" rel="nofollow">leonurine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=liquid chromatography with tandem mass spectrometry&option=203" rel="nofollow">liquid chromatography with tandem mass spectrometry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=primary dysmenorrhoea&option=203" rel="nofollow">primary dysmenorrhoea;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=stachydrine&option=203" rel="nofollow">stachydrine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=traditional Chinese medicine&option=203" rel="nofollow">traditional Chinese medicine;</a> </p> <div class="translation"> 机译：Leonurine;液相色谱;串联质谱;原发性痛经;Stachydrine;中医; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025846858.html">Comparative pharmacokinetics study of leonurine and stachydrine in normal rats 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Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold‐stagnation and blood‐stasis primary dysmenorrhoea after the administration of Leonurus japonicusLeonurus japonicus houtt electuary

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