Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid–liquid microextraction followed by high‐performance liquid chromatography

Mirparizi Ehsan; Rajabi Maryam; Asghari Alireza

摘要

Abstract >In this work, a simple method, namely, tandem dispersive liquid–liquid microextraction, with a high sample clean‐up is applied for the rapid determination of the antidementia drugs rivastigmine and donepezil in wastewater and human plasma samples. This method, which is based on two consecutive dispersive microextractions, is performed in 7?min. In the method, using a fast back‐extraction step, the applicability of the dispersive microextraction methods in complicated matrixes is conveniently improved. This step can be performed in less than 2?min, and very simple tools are required for this purpose. To achieve the best extraction efficiency, optimization of the variables affecting the method was carried out. Under the optimized experimental conditions, the relative standard deviations for the method were in the range of 6.9–8.7%. The calibration curves were obtained in the range of 2–1100?ng/mL with good correlation coefficients, higher than 0.995, and the limits of detection ranged between 0.5 and 1.0?ng/mL. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title类型=“main”>抽象</ title> >在这项工作中，一种简单的方法，即串联色散液体微萃取，用a应用高样品清理用于快速测定废水和人血浆样品中的抗静电剂菌疹和多奈哌齐的快速测定。该方法基于两个连续的分散微萃取物，在7？min中进行。在该方法中，使用快速的后提取步骤，方便地改善了分散微萃取方法在复杂基质中的适用性。该步骤可以在少于2·min的情况下进行，并且为此目的需要非常简单的工具。为了实现最佳的提取效率，进行了影响该方法的变量的优化。在优化的实验条件下，该方法的相对标准偏差在6.9-8.7％的范围内。校准曲线在2-1100·ng / ml的范围内，具有良好的相关系数，高于0.995，检测限范率为0.5和1.0≤ng/ ml。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2018年第10期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mirparizi Ehsan&option=202" target="_blank" rel="nofollow">Mirparizi Ehsan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rajabi Maryam&option=202" target="_blank" rel="nofollow">Rajabi Maryam;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Asghari Alireza&option=202" target="_blank" rel="nofollow">Asghari Alireza;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistrySemnan UniversitySemnan Iran;</p> <p>Department of ChemistrySemnan UniversitySemnan Iran;</p> <p>Department of ChemistrySemnan UniversitySemnan Iran;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=antidementia drugs&option=203" rel="nofollow">antidementia drugs;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=back extraction&option=203" rel="nofollow">back extraction;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=donepezil&option=203" rel="nofollow">donepezil;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=liquid–liquid extraction&option=203" rel="nofollow">liquid–liquid extraction;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=rivastigmine&option=203" rel="nofollow">rivastigmine;</a> </p> <div class="translation"> 机译：防腐剂;背部提取;DeNPezil;液 - 液提取;RIVASTIGMINE; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025846564.html">Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid–liquid microextraction followed by 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨光宇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨光宇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘志华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘志华</a> <span> <a href="/journal-cn-57080/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 分析科学学报 </a> </span> <span> . 2018</span><span>,第1期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-6185_thesis/020221625458.html">超声辅助分散液液微萃取快速测定液体样品中的四溴双酚A及其衍生物</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王雪梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王雪梅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘稷燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘稷燕</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=江桂斌&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,江桂斌</a> <span> <a href="/conference-cn-6185/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第七届全国环境化学学术大会 </a> <span> <span> . 2013</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311854155.html">分散液液微萃取在样品预处理中的应用</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邱玲娜&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邱玲娜</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120100827665.html">基于分散液液微萃取技术的测定大米中荧光增白剂的高效液相色谱串联质谱法</a> <b>[P]</b> . <span> 中国专利： CN109884197A </span> <span> . 2019-06-14</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" 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