Evaluating novel silica hydride‐based stationary phases for the analysis of phytocannabinoids and other psychoactive drugs

Watanabe Seiichiro; Santos Theresa Q.; Matyska‐Pesek Maria T.; Pesek Joseph J.

摘要

Abstract >Three silica hydride based novel chromatographic phases chemically‐bonded with allyloxy‐DL‐alpha‐tocopherol, allylpentafluorophenyl, and 1‐eicosene moieties were evaluated as separation media for selected phytocannabinoids and other substances of abuse. In order to assess column selectivity, a series of reference standards was analyzed and detected by using liquid chromatography with mass spectrometry. Further, quantitative detections of cannabidiol and tetrahydrocannabinol were attempted for the extracts of cannabis plants and cannabidiol gummy formulation. For potential bioanalytical applications, the columns were evaluated for substance screening in a human urine matrix. In summary, the newly developed columns are functional and effective for the analysis of phytocannabinoids and various psychoactive drugs with or without the presence of biological matrices. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >三氧化硅氢化物的基于烯丙基-D1-α-生育酚的基于二氧化硅氢化物的新型色谱相，烯丙烯烯苯基和1-含少糖部分被评价为选定的植物植物和其他物质的分离培养基和滥用的其他物质。为了评估柱选择性，通过使用质谱法使用液相色谱法分析和检测一系列参考标准。此外，试图对大麻植物和大麻胶粘剂的提取物进行大麻和四氢甘油醛的定量检测。对于潜在的生物分析应用，评价柱子在人尿基质中的物质筛选。总之，新开发的柱是具有或不存在生物学基质的存在或不存在生物学基质的植物植物和各种精神活性药物的功能性和有效。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2019年第11期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Watanabe Seiichiro&option=202" target="_blank" rel="nofollow">Watanabe Seiichiro;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Santos Theresa Q.&option=202" target="_blank" rel="nofollow">Santos Theresa Q.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matyska‐Pesek Maria T.&option=202" target="_blank" rel="nofollow">Matyska‐Pesek Maria T.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pesek Joseph J.&option=202" target="_blank" rel="nofollow">Pesek Joseph J.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistrySan José State UniversitySan Jose USA;</p> <p>Department of ChemistrySan José State UniversitySan Jose USA;</p> <p>Department of ChemistrySan José State UniversitySan Jose USA;</p> <p>Department of ChemistrySan José State UniversitySan Jose USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=controlled substances&option=203" rel="nofollow">controlled substances;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=drug analysis&option=203" rel="nofollow">drug analysis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydride stationary phases&option=203" rel="nofollow">hydride stationary phases;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=liquid chromatography‐mass spectrometry&option=203" rel="nofollow">liquid chromatography‐mass spectrometry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=phytocannabinoids&option=203" rel="nofollow">phytocannabinoids;</a> </p> <div class="translation"> 机译：受控物质;药物分析;氢化物固定相;液相色谱 - 质谱;植物植物植物; 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href="/patent-detail/061204250682.html">有机聚合物/二氧化硅复合纳米膜用于植物组织荧光显微分析的方法</a> <b>[P]</b> . <span> 中国专利： CN109596590B </span> <span> . 2021.02.19</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120100419322.html">有机聚合物/二氧化硅复合纳米膜用于植物组织荧光显微分析的方法</a> <b>[P]</b> . <span> 中国专利： CN109596590A </span> <span> . 2019-04-09</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130412231037.html">method for the preparation of an organomodified silica-based material; organomodified silica-based material; use of an organomodified silica-based material; stationary phase separation material; method for preparing a stationary phase separation material; use of stationary phase separation material; and separation column</a> <b>[P]</b> . <span> 外国专利：  BRPI0619969B1 </span> <span> . 2016-05-24</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：制备有机改性的二氧化硅基材料的方法;有机改性的二氧化硅基材料;使用有机改性的二氧化硅基材料;固定相分离材料;制备固定相分离材料的方法;使用固定相分离材料;分离柱 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130414129767.html">COCKTAIL CULTURE MEDIUM FOR EVALUATING ACTIVITY OF PHASE II DRUG METABOLISM ENZYME ACTIVITY AND DRUG INTERACTIONS AND METHOD FOR HIGH-RATE EVALUATING ACTIVITY OF PHASE II DRUG METABOLISM ENZYME USING SAME</a> <b>[P]</b> . <span> 外国专利：  KR101495860B1 </span> <span> . 2015-02-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用相同的方法评估II相药物代谢酶活性和药物相互作用的鸡尾酒培养基和对2相药物代谢酶进行高效率评估的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130436720475.html">METHOD FOR EVALUATING PREDISPOSITION TO PRIMARY PATHOLOGICAL ATTRACTION TO PSYCHOACTIVE DRUGS IN TEENAGERS</a> <b>[P]</b> . <span> 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