Flotation/ultrasound‐assisted microextraction followed by HPLC for determination of fat‐soluble vitamins in multivitamin pharmaceutical preparations

Shahdousti Parvin; Aghamohammadi Mohammad

摘要

Abstract > Dissolved carbon dioxide flotation–emulsification microextraction technique coupled with high‐performance liquid chromatography was developed for separation and determination of fat‐soluble vitamins (A, D <sub>3</sub> , E, and K <sub>3</sub> ) in multivitamin pharmaceutical preparations. Dissolved carbon dioxide flotation was used to break up the emulsion of extraction solvent in water and to collect the extraction solvent on the surface of aqueous sample in narrowed capillary part of extraction cell. Carbon dioxide bubbles were generated in situ through the addition of 300?μL of concentrated hydrochloric acid into the alkaline sample solution at pH?=?11.5 (1% w/v sodium carbonate), which was sonicated to intensify the carbon dioxide bubble generation. Several factors affecting the extraction process were optimized. Under the optimal conditions, the limits of detection were 0.11, 0.47, 0.20 and 0.35?μg/L for A, E, D <sub>3</sub> , and K <sub>3</sub> vitamins in water samples, respectively. The inter‐day and intra‐day precision of the proposed method were evaluated in terms of the relative standard deviation and were 10.5%. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘录</标题> >溶解二氧化碳浮选微萃取技术与高效液相色谱相结合进行分离在多种酰胺素药物制剂中测定脂溶性维生素（A，D <sub> 3 </ sub>，E和K <sub> 3 </ sub>）。使用溶解的二氧化碳浮选在水中分解萃取溶剂的乳液，并在萃取细胞的变窄毛细管部分的水性样品表面上收集萃取溶剂。通过将300·μl浓盐酸加入pH？=α11.5（1％w / v碳酸钠）的碱样品溶液中以原位产生二氧化碳气泡。超声处理以加强二氧化碳泡沫产生。优化了影响提取过程的几个因素。在最佳条件下，对于A，E，D <Sub> 3 </ sub>，检测限为0.11,0.47,0.20和0.35Ωμg/ l，以及水样中的k <sub> 3 </ sub>维生素，分别。在相对标准偏差方面评估所提出的方法的日内和日期的纯度，并且是相对标准偏差的。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shahdousti Parvin&option=202" target="_blank" rel="nofollow">Shahdousti Parvin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Aghamohammadi Mohammad&option=202" target="_blank" rel="nofollow">Aghamohammadi Mohammad;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryIslamic Azad UniversityBoroujerd Iran;</p> <p>Department of ChemistryIslamic Azad UniversityBoroujerd Iran;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dissolved carbon dioxide flotation&option=203" rel="nofollow">dissolved carbon dioxide flotation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fat‐soluble vitamins&option=203" rel="nofollow">fat‐soluble vitamins;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=high‐performance liquid chromatography&option=203" rel="nofollow">high‐performance liquid chromatography;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microextraction&option=203" rel="nofollow">microextraction;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=multivitamin analysis&option=203" rel="nofollow">multivitamin analysis;</a> </p> <div class="translation"> 机译：溶解二氧化碳浮选;脂溶性维生素;高效液相色谱;微萃取;多种维生素分析; 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Filiz Ayyildiz&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">H. 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=苏轶&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 苏轶</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=江安庆&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,江安庆</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=逯平杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,逯平杰</a> <span> <a href="/journal-cn-7281/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 安徽农业科学 </a> </span> <span> . 2011</span><span>,第024期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-food-additives_thesis/020125123298.html">超声辅助萃取RP-HPLC法测定不同产地迷迭香中迷迭香酸含量</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邹盛勤&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邹盛勤</a> <a 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