首页> 外文期刊>Journal of separation science. >Rapid characterization of the absorbed chemical constituents of Tangzhiqing formula following oral administration using UHPLC–Q‐TOF‐MS

【24h】

Rapid characterization of the absorbed chemical constituents of Tangzhiqing formula following oral administration using UHPLC–Q‐TOF‐MS

机译：使用UHPLC-Q-TOF-MS在口服唐芝QING公式的吸收化学成分的快速表征

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Abstract >Tangzhiqing formula, a Chinese herbal formula, is used for the treatment of type II diabetes and prediabetes. Although its effectiveness has been certified by clinical use, its absorbed chemical constituents are not comprehensively represented. Thence, in order to reveal potential bioactive components and metabolism of Tangzhiqing formula, an ultra‐high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry method was developed. A total of 86 absorbed components, including 38 prototype compounds and 48 metabolites, were identified in rat plasma, urine, and feces after oral administration of Tangzhiqing formula. This was the first systematic study on the chemical constituents and metabolic profiling of Tangzhiqing formula. The results indicated that alkaloids and flavonoids were main absorbed components, and glucuronidation and sulfation were the major metabolites. Moreover we concluded that alkaloids and flavonoids first underwent demethylation and hydrolysis reactions before biotransformed to phase II metabolites. This study provided valuable data for safety estimation of Tangzhiqing formula, which will be advantageous for clinical application. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> > Tangzhiqing公式，中草原公式，用于治疗II型糖尿病和前驱脂肪。虽然其有效性已经通过临床使用认证，但其吸收的化学成分没有全面地代表。因此，为了揭示唐志清配方的潜在生物活性成分和代谢，开发了具有四极杆飞行时间质谱法的超高效液相色谱法。在口服唐志庆配方口服施用后，共鉴定出86种吸收组分，其中包括38种原型化合物和48代谢物。这是唐志清配方的化学成分和代谢分析的第一个系统研究。结果表明，生物碱和黄酮类化合物是主要吸收成分，葡萄糖醛和硫化是主要代谢物。此外，我们得出结论，生物碱和黄酮类化合物首先进行了生物转化前的去甲基化和水解反应。本研究提供了唐志清配方的有价值的数据，这对于临床应用是有利的。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35800/'>《Journal of separation science.》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共14页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Xiao‐Lei&option=202" target="_blank" rel="nofollow">Wu Xiao‐Lei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Ming‐Jiang&option=202" target="_blank" rel="nofollow">Wu Ming‐Jiang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Xin‐Ze&option=202" target="_blank" rel="nofollow">Chen Xin‐Ze;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Hong‐Min&option=202" target="_blank" rel="nofollow">Zhang Hong‐Min;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ding Li‐Qin&option=202" target="_blank" rel="nofollow">Ding Li‐Qin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Fu‐Ying&option=202" target="_blank" rel="nofollow">Tian Fu‐Ying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fu Xiao‐Meng&option=202" target="_blank" rel="nofollow">Fu Xiao‐Meng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qiu Feng&option=202" target="_blank" rel="nofollow">Qiu Feng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang De‐Qin&option=202" target="_blank" rel="nofollow">Zhang De‐Qin;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin P. R. China;</p> <p>Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin P. R. China;</p> <p>Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin P. R. China;</p> <p>Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin P. R. China;</p> <p>Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin P. R. China;</p> <p>Tianjin Key Laboratory of Quality Control in Chinese MedicineTianjin ZhongXin Pharmaceuticals R&</p> <p>D CenterTianjin P. R. China;</p> <p>Tianjin Key Laboratory of Quality Control in Chinese MedicineTianjin ZhongXin Pharmaceuticals R&</p> <p>D CenterTianjin P. R. China;</p> <p>Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin P. R. China;</p> <p>Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin P. R. China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=diabetes&option=203" rel="nofollow">diabetes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=metabolic pathways&option=203" rel="nofollow">metabolic pathways;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=metabolites&option=203" rel="nofollow">metabolites;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=prototype components&option=203" rel="nofollow">prototype components;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=traditional Chinese medicine&option=203" rel="nofollow">traditional Chinese medicine;</a> </p> <div class="translation"> 机译：糖尿病;代谢途径;代谢物;原型组件;中医; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025846044.html">Rapid characterization of the absorbed chemical constituents of Tangzhiqing formula following oral administration using UHPLC–Q‐TOF‐MS</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Xiao‐Lei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wu Xiao‐Lei,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Ming‐Jiang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wu Ming‐Jiang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Xin‐Ze&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chen Xin‐Ze,</a> <a href="/journal-foreign-35800/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of separation science. .</a> <span>2018</span><span>,第5期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用UHPLC-Q-TOF-MS在口服唐芝QING公式的吸收化学成分的快速表征</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204114328194.html">Rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of Fuzi-Lizhong pill based on high-throughput HPLC-Q-TOF/MS analysis</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhen Zhang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhen Zhang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Maoyuan Jiang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Maoyuan Jiang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xinyi Wei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xinyi Wei,</a> <a href="/journal-foreign-16260/" target="_blank" rel="nofollow" class="tuijian_authcolor">Chinese Medicine .</a> <span>2019</span><span>,第1期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于高通量HPLC-Q-TOF / MS分析的口服富滋利中丸快速发现大鼠血清中化学成分和吸收成分</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704015361266.html">Rapid discovery of absorbed constituents and metabolites in rat plasma after the oral administration of Zi Shen Wan using high-throughput UHPLC-MS with a multivariate analysis approach</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Xian-Na&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Li Xian-Na,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Aihua&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhang Aihua,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sun Hui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sun Hui,</a> <a href="/journal-foreign-35800/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of separation science. .</a> <span>2016</span><span>,第24期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用高通量UHPLC-MS和多变量分析方法快速口服紫神丸后，快速发现大鼠血浆中吸收的成分和代谢产物</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-257539_thesis/0705010726943.html">IDENTIFICATION AND CHARACTERIZATION OF KEY CHEMICAL CONSTITUENTS FOR THE AUTHENTICATION OF HOODIA GORDONII USING UPLC/ oaTOF MS~(E)</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bharathi Avula&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Bharathi Avula,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kate Yu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kate Yu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yan-Hong Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yan-Hong Wang,</a> <a href="/conference-foreign-257539/" target="_blank" rel="nofollow" class="tuijian_authcolor">American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics .</a> <span>2011</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用UPLC / OATOF MS〜（e）〜（e）〜（e）〜（e）鉴定冠军戈登县的关键化学成分的鉴定与表征</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061419756.html">MALDI-TOF MS as a Rapid Characterization Tool for Economically-Relevant Microalgae.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Barbano, Duane.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Barbano, Duane. </a> <span>2016</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：MALDI-TOF MS作为经济相关微藻的快速表征工具。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040006636922.html">Comprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wei Wei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wei Wei,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Siwei Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Siwei Li,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Linyou Cheng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Linyou Cheng,</a> <span>2021</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于自置组件数据库通过UPLC-Q-TOF-MS在口服给药后yiganmingmu口服液体和吸收原型的综合表征。</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000130910719.html">Comprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wei Wei&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wei Wei,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Siwei Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Siwei Li,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Linyou Cheng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Linyou Cheng,</a> <span>2021</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于自置组件数据库，通过UPLC-Q-TOF-MS在口服给药后yiganmingmu口服液体和吸收原型的综合表征。</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_tibet-science-technology_thesis/0201288950319.html">UHPLC-Q-TOF-MS快速分析藏菖蒲化学成分研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=沈婷婷&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 沈婷婷</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=顿珠次仁&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,顿珠次仁</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蔡瑛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,蔡瑛</a> <span> <a href="/journal-cn-15731/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 西藏科技 </a> </span> <span> . 2021</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-traditional-patent-medicine_thesis/0201272936373.html">UHPLC-Q-TOF-MS/MS法快速鉴定扶元乳膏中化学成分</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谢月&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 谢月</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄文平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄文平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=欧阳辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,欧阳辉</a> <span> <a href="/journal-cn-5710/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中成药 </a> </span> <span> . 2019</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_modernization-traditional-chinese-medicine-materia-medica-world-science-technology_thesis/0201279831944.html">芪红水煎剂化学成分的HPLC-FT-ICR-MS快速表征与HPLC多成分的含量测定</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=肖然&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 肖然</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谢丽媛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,谢丽媛</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=于萍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,于萍</a> <span> <a href="/journal-cn-5736/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界科学技术-中医药现代化 </a> </span> <span> . 2020</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_acta-chinese-medicine-pharmacology_thesis/0201221198993.html">丹参多化学成分的UPLC-LTQ Orbitrap MS快速表征解析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张驰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张驰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王学勇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王学勇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张彩娟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张彩娟</a> <span> <a href="/journal-cn-5724/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中医药学报 </a> </span> <span> . 2018</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_refrigeration-air-conditioning_thesis/0201214034351.html">在LiBr吸收式制冷机中使用索柯洛夫公式计算传热温差的探讨</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董干&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 董干</a> <span> <a href="/journal-cn-7719/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 制冷与空调 </a> </span> <span> . 2003</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-22346_thesis/02022602218.html">使用LC-IT-TOF/MS基于系列成分特征碎片离子进行生脉注射液中化学成分的快速鉴定</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王旋&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王旋</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郑超湳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郑超湳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郝海平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郝海平</a> <span> <a href="/conference-cn-22346/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 岛津公司第七届质谱用户学术交流会 </a> <span> <span> . 2007</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203253357.html">基于UPLC-QTOF快速表征样品中化学成分的方法</a> <b>[P]</b> . <span> 中国专利： CN106950315B </span> <span> . 2019.03.26</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120109431629.html">基于UPLC‑QTOF快速表征样品中化学成分的方法</a> <b>[P]</b> . <span> 中国专利： CN106950315A </span> <span> . 2017-07-14</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130425480225.html">composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion</a> <b>[P]</b> . <span> 外国专利：  BRPI0617987A2 </span> <span> . 2011-08-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130425403408.html">IDENTIFICATION AND CHARACTERIZATION OF PHYTOCHEMICALS/METABOLITES OF DESCHAMPSIA ANTARCTICA EXTRACTS BY LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY LC-MS/MS AND THEIR USES THEREOF.</a> <b>[P]</b> . <span> 外国专利：  IN2009CH02800A </span> <span> . 2011-05-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱-质谱联用LC-MS / MS鉴定和鉴定南极葡聚糖提取物的植物化学/代谢产物及其用途。 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130424911201.html">IDENTIFICATION AND CHARACTERIZATION OF NATURAL CHEMICAL ENTITIES BY LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY LC-MS/MS AND USES THEREOF</a> <b>[P]</b> . <span> 外国专利：  WO2011058423A2 </span> <span> . 2011-05-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：液相色谱-质谱联用LC-MS / MS鉴定和表征天然化学实体及其用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025846044','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);">回到顶部</a> </li> <li class="shouye"> <a href="/">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html">关于掌桥</a></li> <li><a href="/help/helpmap.html">资源导航</a></li> <li><a href="/help/helpguide.html">新手指南</a></li> <li><a href="/help/helpcenter.html">常见问题</a></li> <li><a href="/sitemap.html">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704025846044down" data-source="7," data-out-id="xhKxkK3z6IHY/mJO4sm4ZzIQbu6FuBm4OX9o0vRdH6Kh3D7lH5e2Wiv6l2UXZH4K," data-f-source-id="7" data-title="Rapid characterization of the absorbed chemical constituents of Tangzhiqing formula following oral administration using UHPLC–Q‐TOF‐MS" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="35800" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Rapid characterization of the absorbed chemical constituents of Tangzhiqing formula following oral administration using UHPLC–Q‐TOF‐MS"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.7"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.7"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>