Nuclear Grade Plus Proliferation Grading System for Invasive Ductal Carcinoma of the Breast Validation in a Tertiary Referral Hospital Cohort

摘要

Objectives: For patients with invasive breast cancer, management decisions are informed by tumor grade according to the Nottingham Grading System (NGS), either on its own or as part of the Nottingham Prognostic Index (NPI). A system retaining the nuclear grade element but substituting the two subjective components, mitosis count and tubule formation, of the NGS with a proliferation index based on Ki-67 (MIB-1) has been proposed (nuclear grade plus proliferation [N+P] grading).