Cholest-4-en-3-one attenuates TGF-beta responsiveness by inducing TGF-beta receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells

Chen Chun-Lin; Wu Deng-Chyang; Liu Min-Yun; Lin Ming-Wei; Huang Hung-Tu; Huang Yaw-Bin; Chen Li-Chai; Chen Yu-Yu; Chen Jih-Jung; Yang Pei-Hua; Kao Yu-Chen; Chen Pei-Yu

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Cholest-4-en-3-one attenuates TGF-beta responsiveness by inducing TGF-beta receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells

机译：胆气-4-烯-3-酮通过在MV1LU细胞和结肠直肠腺癌细胞中引起TGF-β受体降解衰减TGF-Beta响应性

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Purpose: The transforming growth factor-beta (TGF-beta) pathway is an important in the initiation and progression of cancer. Due to a strong association between an elevated colorectal cancer risk and increase fecal excretion of cholest-4-en-3-one, we aim to determine the effects of cholest-4-en-3-one on TGF-beta signaling in the mink lung epithelial cells (Mv1Lu) and colorectal cancer cells (HT29) in vitro.

机译：目的：转化生长因子-β（TGF-β）途径是癌症的开始和进展的重要性。由于结肠直肠癌升高的巨大关联，增加了胆汁活性-4-3-on-3的粪便排泄，我们的目的是确定胆汁活-4-3-1对貂皮中TGF-β信号传导的影响肺上皮细胞（MV1LU）和体外结直肠癌细胞（HT29）。

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来源
《Journal of receptor and signal transduction research》 |2017年第6期|共11页
作者
Chen Chun-Lin; Wu Deng-Chyang; Liu Min-Yun; Lin Ming-Wei; Huang Hung-Tu; Huang Yaw-Bin; Chen Li-Chai; Chen Yu-Yu; Chen Jih-Jung; Yang Pei-Hua; Kao Yu-Chen; Chen Pei-Yu;
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作者单位

Natl Sun Yat Sen Univ Dept Biol Sci Kaohsiung 804 Taiwan;

Kaohsiung Med Univ Ctr Stem Cell Res Kaohsiung Taiwan;

Taiwan Ocean Res Inst Natl Appl Res Labs Kaohsiung Taiwan;

Kaohsiung Med Univ Ctr Stem Cell Res Kaohsiung Taiwan;

Natl Sun Yat Sen Univ Dept Biol Sci Kaohsiung 804 Taiwan;

Natl Sun Yat Sen Univ Dept Biol Sci Kaohsiung 804 Taiwan;

Kaohsiung Armed Forces Gen Hosp Dept Pharm Zuoying Branch Kaohsiung Taiwan;

Kaohsiung Armed Forces Gen Hosp Dept Pharm Zuoying Branch Kaohsiung Taiwan;

Kaohsiung Armed Forces Gen Hosp Dept Pharm Zuoying Branch Kaohsiung Taiwan;

Natl Sun Yat Sen Univ Dept Biol Sci Kaohsiung 804 Taiwan;

Natl Sun Yat Sen Univ Dept Biol Sci Kaohsiung 804 Taiwan;

Natl Sun Yat Sen Univ Dept Biol Sci Kaohsiung 804 Taiwan;

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原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
Cholest-4-en-3-one; colorectal cancer; lipid raft; TGF-beta;

机译：Cholest-4-en-3-one;结肠直肠癌;脂质筏;TGF-BETA;

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专利

1. Cholest-4-en-3-one attenuates TGF-beta responsiveness by inducing TGF-beta receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells [J] . Chen Chun-Lin, Wu Deng-Chyang, Liu Min-Yun, Journal of receptor and signal transduction research . 2017,第1a6期

机译：胆气-4-烯-3-酮通过在MV1LU细胞和结肠直肠腺癌细胞中引起TGF-β受体降解衰减TGF-Beta响应性
2. Ligand induced upregulation of the type II transforming growth factor (TGF-beta) receptor enhances TGF-beta responsiveness in COLO-357 cells. [J] . Kleeff J, Wildi S, Friess H, Pancreas . 1999,第4期

机译：配体诱导的II型转化生长因子（TGF-beta）受体的上调增强了COLO-357细胞中TGF-beta的响应能力。
3. Lack of responsiveness to TGF-beta1 in a thyroid carcinoma cell line with functional type I and type II TGF-beta receptors and Smad proteins, suggests a novel mechanism for TGF-beta insensitivity in carcinoma cells. [J] . Heldin NE, Bergstrom D, Hermansson A, Molecular and Cellular Endocrinology . 1999,第1a2期

机译：具有功能性I型和II型TGF-β受体和Smad蛋白的甲状腺癌细胞系中对TGF-β1缺乏响应性，提示癌细胞中TGF-β不敏感的新机制。
4. Smooth Muscle Cell TGF-beta Signaling Study and Multi-Target Quantification upon TGF-beta Stimulation [C] . Xiaoqian Liu, Sarah Parker, Harry (Hal) Dietz, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：平滑肌细胞TGF-Beta信号传导研究和TGF-β刺激的多目标定量
5. Ligand-induced Upregulation of TGF-beta type I and Type II Receptors at the Cell Surface Amplifies the TGF-beta Response [D] . Duan, Dana. 2017

机译：配体诱导的TGF-βI型和II型受体在细胞表面上调放大了TGF-β反应
6. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors [O] . 1994

机译：TGF-β诱导乳腺上皮细胞向间充质细胞的转分化：I型受体的参与
7. Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells. [O] . Chang, J, Lee, C, Hahm, KB, 2011

机译：与ets相关的转录因子ERT（ESX / ESE-1 / ELF3）的过表达诱导Hs578t人乳腺癌细胞内源性TGF-βII型受体表达并恢复TGF-β信号通路。

Cholest-4-en-3-one attenuates TGF-beta responsiveness by inducing TGF-beta receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells

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