Effect of basic periodontal treatment on glycemic control and inflammation in patients with diabetes mellitus type 1 and type 2: controlled clinical trial

摘要

Abstract Objective Compare the response of basic periodontal therapy in diabetes patients with diabetes type 1 and type 2. Materials and methods We selected 70 patients with periodontitis; these were divided into three groups: the control group (n?=?11), systemically healthy patients; test group 1 (n?=?14), patients with type 1 diabetes mellitus; test group 2 (n?=?27), patients with type 2 diabetes mellitus. The groups received basic periodontal treatment after clinical examination. The analyses were performed at 0, 3 and 6?months; clinical parameters included the amount of periodontal and gingival crevicular fluid. Glycated hemoglobin (HbA1c) levels and prostaglandin E2 (PGE2) expression were measured. Results All clinical periodontal parameters evaluated improved in both groups, as did the amount of gingival crevicular fluid. A more significant decrease in HbA1c and PGE2 expression (p??0.05) occurred in test group 1 after 6?months. Conclusion The basic periodontal treatment was more effective for glycemic control in patients with type 1 diabetes mellitus.