A randomized double-blind placebo-controlled study of the efficacy of Clinpro XT Varnish and Gluma dentin desensitizer on dentin hypersensitivity

摘要

Purpose: To evaluate the effect of Clinpro XT Varnish (VXT) paste-liquid, resin-modified glass-ionomer and the resinous dentin desensitizing varnish and Gluma Dentin Desensitizer (Gluma) in treating dentin hypersensitivity (DH). Methods: This short-term (4-week) randomized, double-blind, placebo-controlled, split-mouth study included a total of 119 teeth from 31 individuals which were randomized into three groups: VXT, Gluma, and placebo (warm water). Dentin sensitivity was evaluated by subjects' perception of DH determined by pretreatment tooth sensitivity score (TSS) measured on a 0-10 visual analogue scale (VAS) after tactile (probe) or thermal/evaporative (blast of air) stimuli. TSS was scored at baseline, immediately after treatment (Day 0), after 1 week and after 4 weeks. Results: For both stimuli, mean TSS was significantly decreased in the VXT and Gluma groups at all time points (all, P<0.001) compared with baseline. Regarding comparisons of TSS between treatment groups, the VXT group had significantly lower mean TSS compared with the Gluma group (P<0.05) and placebo control group (P<0.05) at all time points after treatment regardless of stimuli. Group Effect, Time Effect, and Group x Time Effect were all significantly different (all, P<0.001).