Free radical synthesis of cross-linking gelatin base poly NVP/acrylic acid hydrogel and nanoclay hydrogel as cephalexin drug deliver

摘要

In this research, we presented the synthesis of cross-linking poly N-vinyl pyrrolidone /acrylic acid hydrogel and nanoclay hydrogel based on gelatin which named gelatin-g-NVP-AA, gelatin-g-NVP-AA/MMT and used them as cephalexin drug delivery. These hydrogels were fully characterized by FTIR, SEM, TEM, XRD, TGA, DSC, Also, the effect of difference saline solution, temperature, the percentage of nanoclay and time were investigated. In addition, because of pH sensitivity of hydrogels, the swelling, drug loading and drug releasing were studied in different pHs, distilled water and buffers to determine the best condition for each situation which resulted illustrated the universal buffer in pH 8 was the least interaction with hydrogels and had maximum drug loading and releasing in this condition. Antibacterial activities of hydrogels were examined against the S. aureus and the E. coli and showed an interesting result for the loaded drug on gelatin-g-NVP-AA/MMT.