MUCOADHESIVE AND/OR SOL-GEL CO-HYDROGEL SYSTEMS INCLUDING FLUOROALKYLATED (Rf) POLYETHYLENE GLYCOL (PEG) AND Rf-PEG-POLY(ACRYLIC ACID) (PAA) COPOLYMERS, AND METHODS OF MAKING THE SAME AND OF DRUG DELIVERY USING THE SAME

摘要

A block copolymer of the formula R_f-PEG-PAA is disclosed, where R_f comprises a perfluoroalkyl group having at least 3 carbon atoms, bound to an ether oxygen atom directly or through a substituted or unsubstituted alkylene group, PEG is a poly(alkylene glycol) unit having a weight average molecular weight or number average molecular weight of from 1 to 20 kDa, and PAA is one or more poly([meth]acrylic acid) units having a total weight average molecular weight or number average molecular weight of from 0.3 to 10 kDa. A polymer mixture including the block copolymer, a co-hydrogel and a drug delivery vehicle including the polymer mixture, and methods of synthesizing the block copolymer, forming a sol-gel two-phase co-hydrogel, forming a drug delivery vehicle, and delivering a drug to a patient in need thereof are also disclosed.