Biochemical and Hematological Study with the Appreciation of some Immunological Parameters in Thalassemia Patients at Kerbala Province

摘要

Thalassemia is a genetic disorder occurs as a result of the imbalance in the construction of haemoglobir chains cause haemolytic anaemia. This study was aimed to evaluate the serum level of immunologica parameters (Transforming growth factor betal, lnterleukin-23) and hematological parameters ir patients with alpha and beta thalassemia at Kerbala province. And was conducted at Kerbala Children'; Hospital / Thalassemia Department / Kerbala Governorate during the period from November 2017 tc May 2018.Seventy patients involved 48 beta thalassemia patients and 22 alpha thalassemia patient! with age ranged 10-20 years old and ten matched healthy controls were enrolled in the study. Result exposed non-significant increase (p>0.05) in IL-23 and TGF-p in thalassemia patients compared with control group. In p-thalassemia patients the results of the current study indicated that non-significant positive correlation between IL-23 with WBC, there was non-significant positive correlation between TGF-B1 with WBCand PLT. As for P-thalassemia patients the present study showed non-significant positive correlation between IL-23 with Hb and WBC, and there was non-significant positive correlation between TGF-P 1 with WBC. The study showed changes in the immunological parameters in patients with thalassemia of both types, as the serum level of both IL-23 and TGF-pi were raised in addition to changes in hematological and Biochemical parameters.