New wine into old wineskins: PGC‐1α and NF‐κB in obesity and acute pancreatitis

摘要

Abstract Obesity and acute pancreatitis are both proinflammatory conditions. Importantly, obesity increases severity in acute pancreatitis by enhancing inflammation. In a recent issue of The Journal of Pathology , Pérez and Ruiz‐Pérez et al connected obesity and pancreatitis for the first time, through the transcriptional regulator PPARγ coactivator 1α (PGC‐1α). Obesity reduces pancreatic PGC‐1α levels and potentiates not only oxidative but also IL‐6‐mediated inflammatory damage during acute pancreatitis by relieving the binding of PGC‐1α to the NF‐κB subunit p65. Blockade of the IL‐6 receptor subunit gp130 ameliorated tissue injury, substantiating the importance of deregulated PGC‐1α/p65/IL‐6 signaling in obesity and acute pancreatitis. Copyright ? 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.