Nephrotoxicity Reduction by Ceftriaxone plus Vancomycin (Vancoplus) Reconstituted with VRP 1020 in Blood of Mus musculus Mice

摘要

The aim of the present study was to evaluated the effect of the VRP 1020 in reconstitution with fixed dose combination of ceftriaxone-vancomycin (Vancoplus). The mice were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 23+-20癈, humidity 65+-5% and with artificial fluorescent light (10-14 h) of light and dark, respectively. ThirtyMus musculus mice (weighing 30+-5 g) were divided into 5 groups containing 6 mice in each group. Group I: control (normal saline), group II: ceftriaxone (28.57 mg kg~-1 body weight/day) group HI: vancomycin (14.2 mg kg~-1 body weight/day), group IV: ceftriaxone-vancomycin (42.8 mg kg~-1 body weight/day) and group V: ceftriaxone-vancomycin+VRP 1020 (42.8 mg kg~-1 body weight/day).