Physiologically-based, Mechanistic Pharmacokinetic/Pharmacodynamic Modeling to Support Development of T Cell Redirecting Bispecific Agents

Jiang Xiling; Chen Xi; Heald Donald L.; Wang Weirong

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Physiologically-based, Mechanistic Pharmacokinetic/Pharmacodynamic Modeling to Support Development of T Cell Redirecting Bispecific Agents

机译：基于生理学的，机械药代动力学/药效学建模，以支持T细胞的发展重定向双特异性剂

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来源
《Journal of pharmacokinetics and pharmacodynamics》 |2017年第suppla期|共1页
作者
Jiang Xiling; Chen Xi; Heald Donald L.; Wang Weirong;
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Janssen Res &

Dev LLC Janssen Biotherapeut Biol Dev Sci Raritan NJ USA;

Janssen Res &

Dev LLC Janssen Biotherapeut Biol Dev Sci Raritan NJ USA;

Janssen Res &

Dev LLC Janssen Biotherapeut Biol Dev Sci Raritan NJ USA;

Janssen Res &

Dev LLC Janssen Biotherapeut Biol Dev Sci Raritan NJ USA;

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正文语种 eng
中图分类药学;
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专利

1. Physiologically-based, Mechanistic Pharmacokinetic/Pharmacodynamic Modeling to Support Development of T Cell Redirecting Bispecific Agents [J] . Jiang Xiling, Chen Xi, Heald Donald L., Journal of pharmacokinetics and pharmacodynamics . 2017,第Suppla期

机译：基于生理学的，机械药代动力学/药效学建模，以支持T细胞的发展重定向双特异性剂
2. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach [J] . Yoshii Kazuyoshi, Iikura Minami, Hirayama Masamichi, Pharmaceutical research . 2016,第2期

机译：基于生理学的药代动力学和药效学建模，可通过乙酰胆碱抑制乙酰胆碱酯酶（一种新的胃肠动力药物，治疗功能性消化不良）抑制大鼠胃中的乙酰胆碱酯酶。
3. Improving Predictive Modeling in Pediatric Drug Development: Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling [J] . WILLIAM SLIKKER JR., JOHN F. YOUNG, RICHARD A. CORLEY, Annals of the New York Academy of Sciences . 2005,第AUG期

机译：改善儿科药物开发中的预测模型：药代动力学，药效动力学和机理模型
4. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling of Unfractionated Heparin to Predict Activated Clotting Time [C] . Filippo Regorda, Emiliano Vigoni, Giuseppe Pesenti European Symposium on Computer Aided Chemical engineering . 2020

机译：未分割肝素的基于生理学药代动力学和药效学建模预测激活凝血时间
5. Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation in the Development of Spectinamides, a Novel Class of Anti-Tuberculosis Agents [D] . Rathi, Chetan. 2017

机译：Spectinamides，一类新型抗结核药物开发中的转化药代动力学药效学建模和仿真
6. Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents [O] . Xiling Jiang, Xi Chen, Thomas J. Carpenter, 2018

机译：基于靶细胞-生物-效应细胞（TBE）复合体的细胞杀伤模型的开发以表征通过T细胞重定向双特异性试剂的靶细胞消耗
7. Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents [O] . Xiling Jiang, Xi Chen, Thomas J. Carpenter, 2018

机译：基于靶细胞 - 生物学效应细胞（TBE）复合物的细胞杀灭模型的发展，以通过T细胞结转双特异性剂表征靶细胞耗尽
8. Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Minipig Model for Simulation of Low Level Multiple Route CW Agent Exposure [R] . Gearhart, J. M. , Yu, K. O. 2005

机译：开发基于生理学的药代动力学/药效学（pBpK / pD）minipig模型模拟低水平多路CW剂暴露

Physiologically-based, Mechanistic Pharmacokinetic/Pharmacodynamic Modeling to Support Development of T Cell Redirecting Bispecific Agents

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