Suture techniques and patch materials using an in-vitro model for watertight closure of in-utero spina bifida repair

摘要

Purpose: Despite proven benefits of in-utero spina bifida (SB) repair, >= 30% of children at birth have Chiari II malformation or cerebrospinal fluid (CSF) leakage from the repair site. Our study's purpose was to determine CSF pressures in the myelomeningocele sac during mid-gestation in order to design an in-vitro model for evaluating different surgical methods used for watertight closure during in-utero SB repair.