Association of CYP 1A1 CYP CYP 1A1 rs1048943 variant with aggressive periodontitis and its interaction with hyperlipidemia on the periodontal status

摘要

Background and objective CYP 1A1 rs1048943 polymorphism was reported to be correlated with periodontitis; however, its association with aggressive periodontitis (AgP) has not yet been investigated. The aim of the study was to investigate the association between the CYP 1A1 gene rs1048943 variant with generalized aggressive periodontitis ( GA gP) and platelet activation and analyse whether its interaction with hyperlipidemia affects periodontal status in a Chinese population. Methods A case‐control study of 224 GA gP patients and 139 healthy controls was conducted. The clinical parameters of probing depth ( PD ), attachment loss ( AL ) and bleeding index ( BI ) were recorded. Platelet count ( PLT ), platelet distribution width ( PDW ), platelet large cell ratio ( PLCR ), mean platelet volume ( MPV ), serum total cholesterol ( TC ), triacylglycerol ( TG ), high and low‐density lipoprotein ( HDL and LDL ) were also measured. The CYP 1A1 rs1048943 SNP was genotyped by time‐of‐flight mass spectrometry. Logistic and linear regression models were used to measure correlation. Results The CYP 1A1 rs1048943 AG / GG genotype was associated with GA gP ( OR ?=?1.56, 95% CI : 1.01, 2.42), PD , AL and decreased PDW , PLCR and MPV after adjustment for covariates. Gene‐lipid interactions were found between CYP 1A1 rs1048943 and HDL for PD (P interaction? =?0.0033), BI (P interaction? =?0.0311) and AL (P interaction? =?0.0141) and between CYP 1A1 rs1048943 and LDL for PD (P interaction? =?0.013) among patients with GA gP. Conclusion The G allele of the CYP 1A1 rs1048943 gene was associated with GA gP, periodontal status and platelet‐related inflammation status in a Chinese population. Hyperlipidemia could modulate the effect of CYP 1A1 rs1048943 on the periodontal status of GA gP.