Anti-natalizumab antibodies during 8years of natalizumab treatment: effect on natalizumab concentration and 4-integrin receptor saturation

van Kempen Zoe L. E.; van Rossum Johannis A.; Doesburg Djoeke; Claessen Iris; de Vries Annick; ten Brinke Anja; van Oosten Bob W.; Rispens Theo; Killestein Joep

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Anti-natalizumab antibodies during 8years of natalizumab treatment: effect on natalizumab concentration and 4-integrin receptor saturation

机译：抗Navalizumab抗体在纳莱明治疗中的8年期间：对Natalizumab浓度的影响和4-整联素受体饱和

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来源
《Journal of neurology》 |2019年第7期|共2页
作者
van Kempen Zoe L. E.; van Rossum Johannis A.; Doesburg Djoeke; Claessen Iris; de Vries Annick; ten Brinke Anja; van Oosten Bob W.; Rispens Theo; Killestein Joep;
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Univ Amsterdam Amsterdam MS Ctr Neurosci Amsterdam Dept Neurol Med Ctr Boelelaan 1117 NL-1081;

Univ Amsterdam Amsterdam MS Ctr Neurosci Amsterdam Dept Neurol Med Ctr Boelelaan 1117 NL-1081;

Univ Amsterdam Amsterdam MS Ctr Neurosci Amsterdam Dept Neurol Med Ctr Boelelaan 1117 NL-1081;

Sanquin Res Dept Immunopathol Amsterdam Netherlands;

Sanquin Res Dept Immunopathol Amsterdam Netherlands;

Sanquin Res Dept Immunopathol Amsterdam Netherlands;

Univ Amsterdam Amsterdam MS Ctr Neurosci Amsterdam Dept Neurol Med Ctr Boelelaan 1117 NL-1081;

Sanquin Res Dept Immunopathol Amsterdam Netherlands;

Univ Amsterdam Amsterdam MS Ctr Neurosci Amsterdam Dept Neurol Med Ctr Boelelaan 1117 NL-1081;

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正文语种 eng
中图分类神经病学;
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专利

1. Anti-natalizumab antibodies during 8years of natalizumab treatment: effect on natalizumab concentration and 4-integrin receptor saturation [J] . van Kempen Zoe L. E., van Rossum Johannis A., Doesburg Djoeke, Journal of neurology . 2019,第7期

机译：抗Navalizumab抗体在纳莱明治疗中的8年期间：对Natalizumab浓度的影响和4-整联素受体饱和
2. Clinical relevance of serum natalizumab concentration and anti-natalizumab antibodies in multiple sclerosis [J] . VennegoorA., RispensT., StrijbisE.M.M., Multiple sclerosis: clinical and laboratory research . 2013,第5期

机译：血清那他珠单抗浓度和抗那他珠单抗抗体在多发性硬化症中的临床意义
3. Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months. [J] . Oliver B, Fernandez O, Orpez T, Multiple sclerosis: clinical and laboratory research . 2011,第3期

机译：治疗18个月的多发性硬化症患者中抗那他珠单抗抗体的动力学和发生率。
4. Cloning and expression of a biosimilar chimeric monoclonal antibody directed against the human epidermal growth factor receptor and its production in CHO cells for treatment of colo-rectal cancer. [D] . Motiwala, Hatim Maqbulhusen. 2012

机译：针对人表皮生长因子受体的生物仿制药嵌合单克隆抗体的克隆和表达及其在CHO细胞中的产生，用于治疗结肠直肠癌。
5. α4-integrin receptor desaturation and disease activity return after natalizumab cessation [O] . Tobias Derfuss, John M. Kovarik, Ludwig Kappos, 2017

机译：那他珠单抗停止后α4-整合素受体去饱和度和疾病活性恢复
6. Occurrence of antibodies against natalizumab in relapsing multiple sclerosis patients treated with natalizumab [O] . Suf8rensen, Per Soelberg, Hyldgaard Jensen, Poul Erik, Haghikia, Aiden, 2011

机译：那他珠单抗治疗复发性多发性硬化症患者中发生那他珠单抗抗体的发生

Anti-natalizumab antibodies during 8years of natalizumab treatment: effect on natalizumab concentration and 4-integrin receptor saturation

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