Camel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino Rats

摘要

Problem statement: Aluminum has the potential to be toxic in humans and animals. Aluminum is present in many manufactured foods and medicines and also added to drinking water for purification purposes, thus increasing the human exposure to this toxicmetal. Aluminum accumulates mainly in bone, liver, testis, kidneys and brain and resulted in biological dysfunctions. For this reason, many researches are carried out to find natural-made compounds that help in the protection against aluminum induced toxicity in human and animals. The present study was carried out to investigate the protective effects of Camel's milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albinorats of both sexes (230-250 g) were housed in standard metal cages (10 rats/cage). The experimental rats (10 in each group) distributed into two experimental groups with a shared control group received only normal saline orally (Group 1). In experimental first group, a daily dose (0.5 mg kg~(-1) body weight) of Aluminum chloride (A1C13) was orally administrated to the rats for 30 days and named aluminum chloride-treated rats. In experimental second group, the same concentrations of Aluminum chloride was administered orally 10 min after the administration in 1 mL of early morning fresh Camel's milk into the experimental rats for the same period of time and named Camel's milk-Aluminum chloride treated group. Water and food were provided ad libitum. Resu