Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization-case study

de Almeida Sergio M.; Rotta Indianara; Ribeiro Clea E.; Oliveira Michelli F.; Chaillon Antoine; de Pereira Ana Paula; Cunha Ana Paula; Zonta Marise; Bents Joao Franca; Raboni Sonia M.; Smith Davey; Letendre Scott; Ellis Ronald J.

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Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization-case study

机译：CNS遗传分区CNS遗传分区CSF和血清生物标志物的动态CNS遗传分区案例研究

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Despite the effective suppression of viremia with antiretroviral therapy, HIV can still replicate in the central nervous system (CNS). This was a longitudinal study of the cerebrospinal fluid (CSF) and serum dynamics of several biomarkers related to inflammation, the blood-brain barrier, neuronal injury, and IgG intrathecal synthesis in serial samples of CSF and serum from a patient infected with HIV-1 subtype C with CNS compartmentalization.

机译：尽管有抗逆转录病毒治疗的病毒血症有效抑制，但HIV仍可在中枢神经系统（CNS）中复制。这是与炎症，血脑屏障，神经元损伤相关的几种生物标志物的脑脊液（CSF）和血清动力学的纵向研究，CSF和患者感染HIV-1的患者的连续样品中的血脑屏障，神经元损伤和IgG鞘内合成具有CNS划分的亚型C.

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来源
《Journal of neurovirology》 |2017年第3期|共14页
作者
de Almeida Sergio M.; Rotta Indianara; Ribeiro Clea E.; Oliveira Michelli F.; Chaillon Antoine; de Pereira Ana Paula; Cunha Ana Paula; Zonta Marise; Bents Joao Franca; Raboni Sonia M.; Smith Davey; Letendre Scott; Ellis Ronald J.;
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作者单位

Univ Fed Parana Curitiba Parana Brazil;

Univ Fed Parana Curitiba Parana Brazil;

Univ Fed Parana Curitiba Parana Brazil;

Univ Calif San Diego San Diego CA 92103 USA;

Univ Calif San Diego San Diego CA 92103 USA;

Univ Fed Parana Curitiba Parana Brazil;

Univ Fed Parana Curitiba Parana Brazil;

Univ Fed Parana Curitiba Parana Brazil;

Univ Fed Parana Curitiba Parana Brazil;

Univ Fed Parana Curitiba Parana Brazil;

Univ Calif San Diego San Diego CA 92103 USA;

Univ Calif San Diego San Diego CA 92103 USA;

Univ Calif San Diego San Diego CA 92103 USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
HIV; Neurologic manifestations; CSF; Central nervous system; Biomarkers; Compartmentalization; New generation sequence; Subtype; Subtype C;

机译：艾滋病毒;神经系统表现;CSF;中枢神经系统;生物标志物;分区;新一代序列;亚型;亚型C.;

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专利

1. Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization-case study [J] . de Almeida Sergio M., Rotta Indianara, Ribeiro Clea E., Journal of neurovirology . 2017,第3期

机译：CNS遗传分区CNS遗传分区CSF和血清生物标志物的动态CNS遗传分区案例研究
2. Transient and asymptomatic meningitis in human immunodeficiency virus-1 subtype C: a case study of genetic compartmentalization and biomarker dynamics [J] . de Almeida Sergio M., Oliveira Michelli F., Chaillon Antoine, Journal of neurovirology . 2018,第6期

机译：人体免疫缺陷病毒-1亚型C的瞬态和无症状脑膜炎：遗传分区和生物标志物动力学的案例研究
3. Abnormal cerebrospinal fluid (CSF) dynamics in Alzheimer's disease and normal pressure hydrocephalus: CSF-amyloid β precursor protein metabolites as possible biomarkers [J] . LahiriD.K., RayB. European journal of neurology: the official journal of the European Federation of Neurological Societies . 2013,第2期

机译：脑脊髓液（CSF）异常在阿尔茨海默氏病和正常压力脑积水中的动态：CSF淀粉样β前体蛋白代谢物可能是生物标志物
4. CSF proteome characterization Dynamics of plasma proteins and CNS specific proteins in CSF [C] . Jill A. Opsahl, Elise Aasebo, Yngvild Bjorlykke, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：CSF中血浆蛋白质蛋白质和CNS特异性蛋白质的CSF蛋白质组特征动态
5. HIV-1 subtype C mother-to-child transmission: Genetic and immunologic correlates. [D] . Russell, Elizabeth Susan. 2009

机译：HIV-1 C型亚型母婴传播：遗传和免疫学相关。
6. Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization- case study [O] . Sergio M. de Almeida, Indianara Rotta, Clea E. Ribeiro, -1

机译：中枢神经系统基因区划对HIV-1亚型C型脑炎患者脑脊液和血清生物标志物的影响-案例研究
7. Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization—case study [O] . Sergio M. de Almeida, Indianara Rotta, Clea E. Ribeiro, 2017

机译：具有CNS遗传分区的HIV-1亚型C脑炎中CSF和血清生物标志物的动力学

Dynamic of CSF and serum biomarkers in HIV-1 subtype C encephalitis with CNS genetic compartmentalization-case study

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