3D graphene/hydroxypropyl--cyclodextrin nanocomposite as an electrochemical chiral sensor for the recognition of tryptophan enantiomers

摘要

A novel and facile chiral sensing platform has been designed for electrochemical enantiomer recognition based on the coupling of three-dimensional-graphene with hydroxypropyl--cyclodextrin (3D-G/HP--CD). The chiral platform synergistically exploits HP--CD as a supramolecular chiral recognizer and 3D-G as an electrochemical indicator, to recognize tryptophan (Trp) enantiomers by differential pulse voltammetry (DPV) approach with significantly discernable electrochemical signals. The different host-guest interactions of d- and l-Trp with HP--CD reveal high binding affinity to target l-tryptophan for sensing tryptophan isomers. Moreover, we found that the peak currents of the two enantiomers showed a linear response in the concentration range of 0.5-175 M with low detection limits of 9.6 nM and 38 nM for l- and d-Trp (S/N = 3), respectively, exhibiting remarkable sensitivity, fine reproducibility as well as great stability. This process, which is the initial demonstration of cyclodextrin-functionalized 3D-G for an electrochemical chiral recognition application, provides a new strategy for enantiosensing.