Systemic lupus erythematosus.

摘要

Kydroxychloroquine or Chloroquine. Two randomized controlled trials (RCTs) found that hydroxychloroquine or chloroquine reduced arthritis, arthralgia, and joint pain in persons with mild SLE, many of whom were also taking corticosteroids. A third RCT found that hydroxychloroquine reduced flare-ups (defined as arthritis, pleuritis, pericarditis, and cutaneous symptoms) compared with placebo in persons with mild SLE. The RCTs reported no serious adverse effects. The trials were too small and not long enough to comment on the prevention of the progression of existing manifestations, or the occurrence of major organ complications. We found no RCTs comparing hydroxychloroquine versus chloroquine.