High-Fat Diet Induces a Neurometabolic State Characterized by Changes in Glutamate and N-Acetylaspartate Pools Associated With Early Glucose Intolerance: An In Vivo Multimodal MRI Study

摘要

Background: Type-2 diabetes mellitus (T2DM) is a metabolic disorder with a broad range of complications in the brain that depend on the conditions that precede its onset, such as obesity and metabolic syndromes. It has been suggested that neurotransmitter and metabolic perturbations may emerge even before the early stages of T2DM and that highcaloric intake could adversely influence the brain in such states. Notwithstanding, evidence for neurochemical and structural alterations in these conditions are still sparse and controversial.