Estimating the arterial input function from dynamic contrast‐enhanced MRI data with compensation for flow enhancement (II): Applications in spine diagnostics and assessment of crohn's disease

摘要

Background Pharmacokinetic (PK) models can describe microvascular density and integrity. An essential component of PK models is the arterial input function (AIF) representing the time‐dependent concentration of contrast agent (CA) in the blood plasma supplied to a tissue. Purpose/Hypothesis To evaluate a novel method for subject‐specific AIF estimation that takes inflow effects into account. Study Type Retrospective study. Subjects Thirteen clinical patients referred for spine‐related complaints; 21 patients from a study into luminal Crohn's disease with known Crohn's Disease Endoscopic Index of Severity (CDEIS). Field Strength/Sequence Dynamic fast spoiled gradient echo (FSPGR) at 3T. Assessment A population‐averaged AIF, AIFs derived from distally placed regions of interest (ROIs), and the new AIF method were applied. Tofts' PK model parameters (including v p and K trans ) obtained with the three AIFs were compared. In the Crohn's patients K trans was correlated to CDEIS. Statistical Tests The median values of the PK model parameters from the three methods were compared using a Mann–Whitney U ‐test. The associated variances were statistically assessed by the Brown‐Forsythe test. Spearman's rank correlation coefficient was computed to test the correlation of K trans to CDEIS. Results The median v p was significantly larger when using the distal ROI approach, compared to the two other methods ( P 0.05 for both comparisons, in both applications). Also, the variances in v p were significantly larger with the ROI approach ( P 0.05 for all comparisons). In the Crohn's disease study, the estimated K trans parameter correlated better with the CDEIS ( r ?=?0.733, P 0.001) when the proposed AIF was used, compared to AIFs from the distal ROI method ( r ?=?0.429, P ?=?0.067) or the population‐averaged AIF ( r ?=?0.567, P ?=?0.011). Data Conclusion The proposed method yielded realistic PK model parameters and improved the correlation of the K trans parameter with CDEIS, compared to existing approaches. Level of Evidence : 3 Technical Efficacy Stage 1 J. Magn. Reson. Imaging 2018;47:1197–1204.