Quantification and Comparison of 4D-Flow MRI-Derived Wall Shear Stress and MRE-Derived Wall Stiffness of the Abdominal Aorta

摘要

Purpose: Aortic wall shear stress (WSSFlow) alters endothelial function, which in-turn changes aortic wall stiffness leading to remodeling in different disease states. Therefore, the aims of this study are to determine normal physiologic correlations between: (1) Magnetic Resonance Elastography (MRE)-derived aortic wall stiffness (WSMRE) and WSSFlow; (2) WSMRE and mean velocity; (3) WSMRE and pulse wave velocity (PWV);( 4) WSMRE and mean peak flow; and (5) WSMRE, WSSFlow and age using MRE and 4D-flow MRI in the abdominal aorta in healthy human subjects.