Quantification and comparison of 4D-Flow MRI-derived wall shear stress and MRE-derived wall stiffness of the abdominal aorta

摘要

PurposeAortic wall shear stress (WSSFlow) alters endothelial function, which in-turn changes aortic wall stiffness leading to remodeling in different disease states. Therefore, the aims of this study are to determine normal physiologic correlations between: 1) MRE-derived aortic wall stiffness (WSMRE) and WSSFlow; 2) WSMRE and mean velocity; 3) WSMRE and pulse wave velocity (PWV); 4) WSMRE and mean peak flow; and 5) WSMRE, WSSFlow and age using magnetic resonance elastography (MRE) and 4D-flow MRI in the abdominal aorta in healthy human subjects.