An asymmetric synthesis of L-[3-~(13)C]alanine

Kazuhiko Takatori; Sanae Toyama; Shoko Narumi; Seishiro Fujii; Masahiro Kajiwara

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An asymmetric synthesis of L-[3-~(13)C]alanine

机译：L- [3-〜（13）C]丙氨酸的不对称合成

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L-[3-~(13)C]Alanine was synthesized from [~(13)C]methyl iodide by using Dellaria's oxazinone, prepared from phenyl[2-~(13)C]bromoacetate and (S)-2-phenylglycinol, as a chiral glycine equivalent. Alkylation of the oxazinone with [~(13)C]methyl iodide was achieved with high diastereoselectivity. Hydrolysis and removal of the chiral auxiliary of the alkylated oxazinone gave L-[3-~(13)C]alanine.

机译：通过使用由苯基制备的乳腺素的恶唑啉酮从[〜（13）C]甲基碘合成L- [3-〜（13）C]丙氨酸[2-〜（13）C]溴乙酸酯和（s）-2-苯基甘油醇作为手性甘氨酸等同物。通过高非对映选择性实现了与[〜（13）C]甲基碘的恶唑啉酮的烷基化。水解和除去烷基化恶嗪酮的手性助剂，得到了L- [3-〜（13）C]丙氨酸。

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来源
《Journal of Labelled Compounds and Radiopharmaceuticals》 |2004年第1期|共4页
作者
Kazuhiko Takatori; Sanae Toyama; Shoko Narumi; Seishiro Fujii; Masahiro Kajiwara;
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作者单位

Department of Medicinal Chemistry Meiji Pharmaceutical University 2-522-1 Noshio Kiyose-shi Tokyo 204-8588 Japan;

Univ Roma La Sapienza Dipartimento Metodi &

Modelli Matemat Sci Applica Rome Italy;

Univ Roma La Sapienza Dipartimento Metodi &

Modelli Matemat Sci Applica Rome Italy;

Univ Roma La Sapienza Dipartimento Metodi &

Modelli Matemat Sci Applica Rome Italy;

Univ Roma La Sapienza Dipartimento Metodi &

Modelli Matemat Sci Applica Rome Italy;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
L-3-~(13)Calanine; ~(13)Cmethyl iodide; chiral glycine equivalent; oxazinone;

机译：l-[3-〜（13）c]丙氨酸;[〜（13）c]甲基碘;手性甘氨酸等同物;恶唑啉酮;
入库时间 2022-08-20 09:30:09

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1. An asymmetric synthesis of L-[3-~(13)C]alanine [J] . Kazuhiko Takatori, Sanae Toyama, Shoko Narumi, Journal of Labelled Compounds and Radiopharmaceuticals . 2004,第1期

机译：L- [3-〜（13）C]丙氨酸的不对称合成
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An asymmetric synthesis of L-[3-~(13)C]alanine

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