ELECTROPHORETIC STUDY OF DNA FOR DETECTING DRUG INDUCED CANCER CELL DEATH

摘要

Cancer cells are characterized by their resistance to apoptosis due to various factors. The DNA of apoptotic cells shows unique fragmented pattern in gel electrophoresis experiments. Electrophoresis has proved a powerful molecular method to distinguish between normal and apoptotic cells. Analysis of DNA fragmentation pattern also allows to distinguish between normal and transformed cells. Liposome encapsulated antitumor drugs have been shown to be efficiently delivered to target cells and produce apoptosis in vitro using electrophoresis method.