Synthesis of 1,4-Disubstituted 1,2,3-Triazoles via 1,3-Dipolar Cycloaddition/C-N Coupling of Propargyl Alcohols/amines and Aryl Azides

摘要

1,4-Disubstituted 1,2,3-triazoles are prepared through the 1,3-dipolar cycloaddition of propargyl (alcohols/amines) and aryl azides in the presence of a mixture of Cu(OAc)(2).H2O and NaAs as the catalyst. This method offers the advantages of mild experimental conditions, operational simplicity, and high-to-excellent reaction yields.