Dysfunction of B-cell lymphoma 2/adenovirus E1B 19 KD interacting protein 3 in decidua is involved in the pathogenesis of preeclampsia

摘要

Objectives: Abnormal decidualization is a contributing factor for the development of preeclampsia. BCL-2/adenovirus E1B 19KD interacting protein 3 (BNIP3) has been identified as an apoptosis regulator in many tumors. Furthermore, our previous studies showed that both BNIP3 and cleaved-caspase 3 were significantly decreased in the decidual tissue of preeclampsia. Therefore, we hypothesized that BNIP3 might affect the development of preeclampsia by regulating both decidualization and apoptosis of decidual cells.