Application of novel Ni(II) complex and ZrO 2 nanoparticle as mediators for electrocatalytic determination of N -acetylcysteine in drug samples

摘要

Abstract The electrooxidation of N -acetylcysteine ( N -AC) was studied by a novel Ni(II) complex modified ZrO 2 nanoparticle carbon paste electrode [Ni(II)/ZrO 2 /NPs/CPE] using voltammetric methods. The results showed that Ni(II)/ZrO 2 /NPs/CPE had high electrocatalytic activity for the electrooxidation of N -AC in aqueous buffer solution (pH?=?7.0). The electrocatalytic oxidation peak currents increase linearly with N -AC concentrations over the concentration ranges of 0.05–600μM using square wave voltammetric methods. The detection limit for N -AC was equal to 0.009μM. The catalytic reaction rate constant, k h , was calculated (7.01?×?10 2 ?M ?1 ?s ?1 ) using the chronoamperometry method. Finally, Ni(II)/ZrO 2 /NPs/CPE was also examined as an ultrasensitive electrochemical sensor for the determination of N -AC in real samples such as tablet and urine. Graphical abstract In this study we describe a novel electrochemical sensor employing new Ni (II) complex and ZrO 2 nanoparticle in carbon paste matrix for voltammetric determination of N -acetylcysteine in drug samples. Display Omitted Highlights ? A new Ni(II) complex synthesized and used for electrocatalysis of N -acetylcysteine. ? A Coupling Ni(II) complex and ZrO 2 nanoparticles improved ability of sensor for trace analysis. ? This sensor was used for the determination of N -acetylcysteine in drug samples.