Safety and efficacy of fixed‐dose 10?mg daily isotretinoin treatment for acne vulgaris in Malaysia

摘要

Summary Introduction Low‐dose isotretinoin is used to reduce side effects albeit higher relapse. This study aimed to determine the efficacy and safety of fixed‐dose 10?mg daily isotretinoin for the treatment of acne. Methods This prospective study was performed between 2011 and 2015. All 150 patients were given 10?mg daily isotretinoin until a cumulative dose of 90–110?mg/kg. Results The mean age was 26.6?years with 64.7% moderate acne, 29.3% severe, and 6% very severe. The mean cumulative dose was 98.8?±?6.05?mg/kg. All 150 patients had total clearance with a mean time to clearance of 24.0?weeks. Patients with severe/very severe acne had higher cumulative dosage (102.1 vs . 97.0, P ??0.001) and longer duration to clearance (32.9?weeks vs . 19.1?weeks, P ??0.001). Mild relapse was seen in 4%. The mean time to relapse was 32.3?weeks. Lip dryness was the commonest side effects (100%). Mild transient elevation of liver enzymes was detected in 3.3% and a slight increase of serum lipid in 2.7% with no treatment discontinuation. Conclusion Fixed‐dose 10?mg daily treatment with isotretinoin until a cumulative dose of 90–110?mg/kg is safe with low relapse rate.