Frequency content and sex difference of the Frank lead signal-averaged ECG in a population with significant coronary artery disease. Comparison with concurrent 12-lead ECG morphology.

摘要

The 12-lead electrocardiogram (ECG) and a 100-beat signal-averaged Frank lead ECG (SAECG) at a sampling rate of 1,000 Hz and with 16-bit resolution were recorded from 52 women and 256 men with significant coronary artery disease presenting for coronary artery revascularization. The QRS portion of each Frank lead was digitally filtered in four bandwidths: 0-10, 10-60, 60-150, and 150-250 Hz. The root-mean-square (RMS) voltage of each filtered signal was calculated as an absolute value and normalized as a percentage of the sum of the four filters, creating 27 variables. Three groups were formed using the presenting 12-lead ECG: N-ECG, ST-ECG, and MI-ECG. Despite variation in 12-lead morphology, concordance was dominant in the RMS values of the SAECG in sex comparisons within and between groups. There was significant sex difference of the RMS values in 6 of the 15 absolute RMS variables within the three groups. Women had no significant between-group difference, and men had a significant between-group differences in five absolute values and one normalized RMS value. P was considered significant at < .05.