Development of curcumin-loaded silk fibroin nanoparticles as drug delivery vehicle for the treatment of ischemic stroke for patients in nursing care in hospitals

摘要

Herein, we showed the synthesis of Curcumin-loaded silk fibroin (SF) nanoparticles (NPs) (Curc-SFNs) with physical adsorption technique, which is more scalable than approaches that are earlier reported utilizing ionic liquids. The outcomes represented that the formed NPs were 152–170?nm in diameter with an approximate zeta potential of-34 mV. Further, the drug release studies showed Curcumin release was greater for the Curc-SFNs, and the burst release was noticed for the NPs in the initial 5?h, which reached a highest value of about 35% of the drug loaded, because of high drug concentration onto the surface, which made the release easier. In conclusion, Curc-SFNs constitute a very good delivery system with high prospectus to ischemic stroke by long-term and local sustained drug delivery.