Elaboration of sponge-like biodegradable cationic particles via double-emulsion solvent evaporation

摘要

Researchers work on different optimization methods to come up with preparation methods, which show the desired or targeted outcomes. Moreover, nowadays, research is more focused on developing formulations which contain biodegradable polymers. The objective of the present systematic study was to achieve the abovementioned goals by using a cationic ammonio methacrylate copolymer (Eudragit (R) RS100). A Double-emulsion solvent evaporation technique was used. This methodology was chosen because the particles formed by this method allow encapsulation of both hydrophilic and hydrophobic active molecules. It also has applications in diverse fields such as drug delivery, food, cosmetics, and pharmaceutical industries.The aim of this research work was to investigate the influence of various process control parameters, such as stabilizer chemical nature and amount, ultra Turrax (R) stirring speed and time, the morphology, size, and size distribution of the final dispersions. Then, the prepared particles were characterized using a Scanning Electron Microscope (SEM) and a Laser Diffraction Particle Size Analyzer. This study helped us to know which parameters have a drastic effect on the colloidal properties of the particles.