Synthesis, characterization, crystal structure, and antimicrobial studies of novel thiourea derivative ligands and their platinum complexes

摘要

N, N-Di-R-N'-(4-chlorobenzoyl) thiourea (Di-R: diethyl, di-n-propyl, din-butyl and diphenyl) ligands (HL1-4) and their Pt(II) complexes (cis[ Pt(L1-4-S, O)(2)]) have been synthesized and structurally characterized by elemental analyses, FT-IR and NMR spectroscopy. HL2 ligand and cis-[ Pt(L-4-S, O)(2)] metal complex have been also characterized by a single-crystal X-ray diffraction study. HL2, C14H19ClN2OS, crystallizes in the monoclinic space group P2(1)/n (no. 14), with Z = 4, and unit cell parameters, a = 11.1405(16) angstrom, b = 9.7015(12) angstrom, c = 14.790(2) angstrom, beta = 106.547(7)degrees. The cis-[ Pt(L-4-S, O)(2)], C40H28Cl2N4O2PtS2 : triclinic, space group P-1 (no. 2), a = 8.9919(3) angstrom, b = 14.7159(6) angstrom, c = 15.7954(6) angstrom, a = 113.9317(18)degrees, beta = 97.4490(18)degrees, and. = 105.0492(16)degrees. Single crystal analysis of complex, cis-[ Pt(L1-4-S, O)(2)], revealed that a square planar coordination geometry is formed around the platinum atom by two sulfur and two oxygen atoms of the related ligands, which are in a cis configuration. In addition, the thiourea derivative ligands and their complexes were evaluated for both their in-vitro antibacterial and antifungal activity. The results have been reported, explained, and compared with fluconazole and ampicillin, used as reference drugs.